Protein Details: Zinc-activated ligand-gated ion channel

Protein ID

ICDB_Pro_0937

Protein Name

Zinc-activated ligand-gated ion channel

Gene Name

ZACN; L2; LGICZ; LGICZ1; ZAC

Organism

Homo sapiens (Human)

Length

412 amino acids

AlphaFoldDB

AF-Q401N2-F1-model_v4.pdb

Function

Sequence

MMALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNVNLSKKVQESIQIPNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPWESLWTPRLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYALSNTAMELEFQAHVVNEIVSVKREYVVYDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPRGEQREHGNPGPHPAEEPSRGVKGSQRSWPETADRIFFLVYVVGVLCTQFVFAGIWMWAACKSDAAPGEAAPHGRRPRL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Long Qt Syndrome and Epilepsy

Location

Detected in pancreas; brain; liver; placenta; trachea; kidney; spinal cord; stomach and fetal brain. In the adult brain region expression is detected in the hippocampus; striatum; amygdala and thalamus.